Search results for "A domain"

PCSK9-D374Y mediated LDL-R degradation can be functionally inhibited by EGF-A and truncated EGF-A peptides: An in vitro study.

2019

Abstract Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low density lipoprotein receptor (LDLR) through the LDLR epidermal growth factor-like repeat A (EGF-A) domain and induces receptor internalization and degradation. PCSK9 has emerged as a novel therapeutic target for hypercholesterolemia. Clinical studies with PCSK9 inhibiting antibodies have demonstrated strong LDL-c lowering effects, but other therapeutic approaches using small molecule inhibitors for targeting PCSK9 functions may offer supplementary therapeutic options. The aim of our study was to evaluate the effect of synthetic EGF-A analogs on mutated (D374Y) PCSK9-D374Y mediated LDLR degradatio…

Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer

2016

Background & Aims Many different types of cancer cells have chromosome instability. The hippo pathway leads to phosphorylation of the transcriptional activator yes-associated protein 1 (YAP1, YAP), which regulates proliferation and has been associated with the development of liver cancer. We investigated the effects of hippo signaling via YAP on chromosome stability and hepatocarcinogenesis in humans and mice. Methods We analyzed transcriptome data from 242 patients with hepatocellular carcinoma (HCC) to search for gene signatures associated with chromosomal instability (CIN); we investigated associations with overall survival time and cancer recurrence using Kaplan–Meier curves. We analyze…

2018

Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns. The amino acid composition in the 38 proteomes studied showcase the greater variability found in archaea and bacteria species compared to eukaryotes. When focusing on domains and linkers, we describe the preferential u…

Domain wall energy in quasi-one-dimensional Fe/W(110) nanostripes

2003

The magnetic susceptibility in Fe/W(110) nanostripes decreases exponentially with increasing temperature according to an Arrhenius law which indicates a quasi-one-dimensional behavior. The interface energy of the Arrhenius law corresponds to the domain wall energy of a domain wall across a single stripe, separating fluctuating regions of homogeneous magnetization. The domain wall energy increases linearly with the width of the stripes, revealing a negative offset which we attribute to boundary effects. Domain wall energies have been determined for Fe/W(110) nanostripes coated with Au and Pd and are compared to values for uncoated Fe/W(110) nanostripes in ultrahigh vacuum.

Front propagation in the one-dimensional autocatalyticA+B→2Areaction with decay

1999

We consider front propagation in the autocatalytic scheme $A+\stackrel{\ensuremath{\rightarrow}}{B}2A,$ where we also allow the A particles to decay, $\stackrel{\ensuremath{\rightarrow}}{A}0,$ with a constant decay rate $\ensuremath{\beta}.$ In a one dimensional, discrete, situation the A domain moves as a pulse, and its dynamics differs from what is found in higher dimensions. Thus the velocity of the pulse tends to a finite value when $\ensuremath{\beta}$ approaches from below the critical value ${\ensuremath{\beta}}_{c},$ at which pulses die out. On the other hand, when approaching ${\ensuremath{\beta}}_{c}$ from above, the mean lifetime of the pulse grows as $T\ensuremath{\propto}(\ensu…

Absolute continuity of mappings with finite geometric distortion

2015

Suppose that ⊂ R n is a domain with n ≥ 2. We show that a continuous, sense-preserving, open and discrete mapping of finite geometric outer distortion with KO(·,f) ∈ L 1/(n 1) loc () is absolutely continuous on almost every line parallel to the coordinate axes. Moreover, if U ⊂ is an open set with N(f,U) 0 depends only on n and on the maximum multiplicity N(f,U).

Stochastic equation of population dynamics with diffusion on a domain

2003

We consider Lotka-Volterra competition model with diffusion in a territorial domain with a stochastic perturbation which represents the random variations of environment conditions. We prove the existence, the uniqueness and the positivity of the solution. Moreover, the stochastic boundedness of the solution is analized.

Deinococcus radiodurans' SRA-HNH domain containing protein Shp (Dr1533) is involved in faithful genome inheritance maintenance following DNA damage

2018

WOS:000452343100012; International audience; Background: Deinococcus radiodurans R1 (DR) survives conditions of extreme desiccation, irradiation and exposure to genotoxic chemicals, due to efficient DNA breaks repair, also through Mn2+ protection of DNA repair enzymes. Methods: Possible annotated domains of the DR1533 locus protein (Shp) were searched by bioinformatic analysis. The gene was cloned and expressed as fusion protein. Band-shift assays of Shp or the SRA and HNH domains were performed on oligonucleotides, genomic DNA from E. coif and DR. slip knock-out mutant was generated by homologous recombination with a kanamycin resistance cassette. Results: DR1533 contains an N-terminal SRA…

Rough Set Algebras as Description Domains

2009

Study of the so called knowledge ordering of rough sets was initiated by V.W. Marek and M. Truszczynski at the end of 90-ies. Under this ordering, the rough sets of a fixed approximation space form a domain in which every set ↓ is a Boolean algebra. In the paper, an additional operation inversion on rough set domains is introduced and an abstract axiomatic description of obtained algebras of rough set is given. It is shown that the resulting class of algebras is essentially different from those traditional in rough set theory: it is not definable, for instance, in the class of regular double Stone algebras, and conversely.

Prime Rings Whose Units Satisfy a Group Identity. II

2003

Abstract Let R be a prime ring and 𝒰(R) its group of units. We prove that if 𝒰(R) satisfies a group identity and 𝒰(R) generates R,then either R is a domain or R is isomorphic to the algebra of n × n matrices over a finite field of order d. Moreover the integers n and d depend only on the group identity satisfed by 𝒰(R). This result has been recently proved by C. H. Liu and T. K. Lee (Liu,C. H.; Lee,T. K. Group identities and prime rings generated by units. Comm. Algebra (to appear)) and here we present a new different proof.